It seems in 10.5 the Application Switcher now receives dropped files -- drag a file, press Command-Tab, then drop the dragged file onto an application in the switcher window.[robg adds: While testing this hint, I noticed another change in the app switcher: pressing "H" is now a toggle. In 10.4, pressing "H" would hide the currently-highlighted app in the switcher, but there was no way to unhide it again. In 10.5, "H" merely flips the hidden state of the chosen app. Note that this is not a duplicate of this hint, which simply noted you could drag, Command-Tab to a new app, then drop. Now, finally, you can drop directly onto icons in the Command-Tab palette itself.]

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